A. Murgo. This can last for around 10 days, but if it lasts longer see your doctor. 2-[[2-ethyl-6-[4-[2-(3-hydroxyazetidin-1-yl)-2-oxoethyl]piperazin-1-yl]-8-methylimidazo[1,2-a]pyridin-3-yl]-methylamino]-4-(4-fluorophenyl)-1,3-thiazole-5-carbonitrile, 21. Two (12%) patients in the GLPG1690 group had events that were judged to be related to treatment. chest pain. Bloomberg the Company & Its Products The Company & its Products Bloomberg Terminal Demo Request Bloomberg Anywhere Remote Login Bloomberg Anywhere Login Bloomberg Customer Support Customer Support Galapagos is currently pursuing the development of GLPG1690, a small … found that injection site pain, fatigue, headache, and aches and pains were commonly reported after vaccination. GLPG1690 is an investigational drug and its efficacy and safety have not been established by any regulatory agency. Statins are effective at lowering cholesterol and protecting against a heart attack and stroke, although they may lead to side effects for some people. To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Genetic and Rare Diseases Information Center, U.S. Department of Health and Human Services, The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. AusVaxSafety said these symptoms were known to occur after vaccination. The most frequent events in the GLPG1690 group were infections and infestations (ten events) and respiratory, thoracic, and mediastinal disorders (eight events) with no apparent differences from the placebo group. The results of four large CV outcome trials with GLP-1 agonists are now available. Listing a study does not mean it has been evaluated by the U.S. Federal Government. This study is the extension of the double-blind study GLPG1690-CL-204 (NCT03798366). A. Murgo 1. x. … Check with your doctor immediately if any of the following side effects occur: More common . The most The most frequent events in the GLPG1690 group were infections and infestations (ten events) and respiratory, thoracic, and The main purpose of the study is to see how GLPG1690 is tolerated in participants with systemic sclerosis and whether there are any side effects in a long-term treatment period. But if you're experiencing side effects days after getting the … Serious adverse events were seen in two patients in the … Call your doctor for medical advice about side effects. Study record managers: refer to the Data Element Definitions if submitting registration or results information. A Clinical Study to Test Long Term Safety of GLPG1690 for Patients With Systemic Sclerosis Study Purpose This study is the extension of the double-blind study GLPG1690-CL-204 (NCT03798366). The main purpose of the study is to see how GLPG1690 is tolerated in participants with systemic sclerosis and whether there are any side effects in a long-term treatment period. Please remove one or more studies before adding more. Some side effects — such as heartburn, diarrhea, and abdominal discomfort — might occur when a person consumes more than 5 grams (g) of … Statin side effects: Weigh the benefits and risks. No such effects have previously been reported in Thailand or other countries, she added. Technical details about GLPG1690, learn more about the structure, uses, toxicity, action, side effects and more 5-thiazolecarbonitrile, 2-((2-ethyl-6-(4-(2-(3-hydroxy-1-azetidinyl)-2-oxoethyl)-1-piperazinyl)-8-methylimidazo(1,2-a)pyridin-3-yl)methylamino)-4-(4-fluorophenyl)-, 2-[[2-ethyl-6-[4-[2-(3-hydroxyazetidin-1-yl)-2-oxoethyl]piperazin-1-yl]-8-methylimidazo[1,2-a]pyridin-3-yl]-methylamino]-4-(4-fluorophenyl)-1,3-thiazole-5-carbonitrile, InChI=1S/C30H33FN8O2S/c1-4-24-29(35(3)30-34-27(25(14-32)42-30)20-5-7-21(31)8-6-20)39-15-22(13-19(2)28(39)33-24)37-11-9-36(10-12-37)18-26(41)38-16-23(40)17-38/h5-8,13,15,23,40H,4,9-12,16-18H2,1-3H3, CCC1=C(N2C=C(C=C(C2=N1)C)N3CCN(CC3)CC(=O)N4CC(C4)O)N(C)C5=NC(=C(S5)C#N)C6=CC=C(C=C6)F, Glpg1690, 1628260-79-6, Glpg-1690, Chembl3828074, Unii-i02418v13w, I02418v13w, Chromatography (TLC / LC / HPLC / UPLC / GC), Complete Pharmacopoeial / Compendial Testing, Bioanalytical & Biomarker Testing Services, Bioequivalence / Clinical / Pre-Clinical Testing, Calculation and Modeling of Pharmacokinetic Parameters, Protein isolation, identification and characterization, Electrical Conductivity / High Voltage Leak Detection (HVLD), Mass Flow / Mass Extraction Leak Detection, European and Japanese Pharmacopoeia (EP & JP) Container Testing, ASTM and ISTA Distribution Simulation Testing, Environmental Conditioning, Cycling and Simulation Testing, Controlled / Immediate / Modified Release, Health / Dietary Supplement (Nutraceutical), Low Temperature / Cryogenic Condition (-78 °C), Pharmacokinetics / Pharmacodynamics / Pharmacometrics, Clinical Research Translation / Validation, Pharmacovigilance / Product Lifecycle Management, High Potent / Biologic / Controlled Substance, Customization (Anodizing, Siliconization, Plastic Coating), Media / Public Relations / Communications, Methacrylic Acid - Ethyl Acrylate Copolymer, Methacrylic Acid Methyl Methacrylate Copolymer, Polyvinyl Alcohol Graft Polyethylene Glycol Copolymer, Betadex Sulfobutyl Ether Sodium Excipient, Hydroxypropyl methylcellulose acetate succinate, Cross Linked Sodium Carboxymethylcellulose, Hepatology (Liver, Pancreatic, Gall Bladder). Serious adverse events were seen in two patients in the placebo … Two (12%) patients in the GLPG1690 group had events that were judged to be related to treatment. Talk with your doctor and family members or friends about deciding to join a study. Among the 37,011 people who reported one or more adverse events, the most common were fatigue, headache, muscle and body aches, injection site pain and chills. GLPG1690 was generally well tolerated; First autotaxin inhibitor to show effect in IPF patient trial; GLPG1690 expected to progress to … The rapid development of COVID-19 vaccines has people asking questions. Read our, ClinicalTrials.gov Identifier: NCT03976648, Interventional
To answer this question, scientists study the available evidence, and while the rules of science do not allow scientists to say that … FLORA was an … Drug information provided by: IBM Micromedex. Search for articles by this author. Short-term side effects (i.e., those that happen in the days after a vaccine has been given) are readily apparent because of clinical trial reports and personal experiences, but people also wonder about possible long-term effects of these vaccines. Condition or disease. The Autotaxin Inhibitor GLPG1690 Attenuates Bleomycin-Induced Pulmonary Fibrosis in Mice. Along with its needed effects, a medicine may cause some unwanted effects. Individual Participant Data (IPD) Sharing Statement: Studies a U.S. FDA-regulated Drug Product: Studies a U.S. FDA-regulated Device Product: Number of adverse events (AEs) as assessed by Common Terminology Criteria for Adverse Events (CTCAE) version 5.0 [ Time Frame: From start of study medication in study GLPG1690-CL-204 through day 30 after last dose in study GLPG1690-CL-206 ]. The most commonly reported side effect from the vaccine is injection site reaction. These treatments appear to slow disease progression but are frequently associated with side effects potentially limiting the use in clinical practice. These have … The main purpose of the study is to see how GLPG1690 is tolerated in participants with systemic sclerosis and whether there are any side effects in a long-term … To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. RELATED: How worried should you be about the blood clot risk? Search for articles by this author. Common lisinopril side effects may include: headache, dizziness; cough; or. Based on the data, the most common side effects were: flu-like illness; headache; fatigue; injection-site reactions B. Canciani. For more information about GLPG1690: www.glpg.com/glpg-1690 Male or female subjects who completed the 24-week treatment period of Study GLPG1690-CL-204 and who according to the investigator's judgment may benefit from long-term treatment with GLPG1690. The main purpose of this study is to see how GLPG1690 works together with your current standard treatment on your lung function and IPF disease in general. Any condition or circumstances that, in the opinion of the investigator, may make a subject unlikely or unable to complete the study or comply with study procedures and requirements.
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